The Nicktoons discovered when they got cooties.
Before SpongeBob, Jimmy, Timmy and B.O.B. started training, Jenny comes in the HQ with some leaves which she informs are "organic moisturizers". She rubs it on herself then B.O.B., then Jimmy, then Timmy until SpongeBob tells them to start training (while Timmy eats his leaves). The zookeeper tells the kids to go back to the bus while Jenny flies in the house so she can be undetected.
Meanwhile, at Sheen's house, Sheen observes at a bunch of kids running from a girl who claims to have "cooties'. When Sheen raises his feet in terror, Patrick hops and hugs them, but Sheen throws him away. At the HQ, SpongeBob, Jimmy, Timmy and B.O.B. were training SUMO style, but while Jimmy and Timmy charge bellies at each other, Patrick is squashed between them (which B.O.B. calls a penalty). Chester and Sheen are seen taking some of SpongeBob, Jimmy, Timmy and B.O.B.'s tools and weapons, but were spotted. Chester explains that the humans are spreading something called "cooties". When all of them observe the kids, they becomes convinced. They found Jenny in Burt's habitat with Jenny scratching Burt. Jenny then itches and the others claims that Jenny has the cooties. The others panicked, especially Sheen. While Sheen panics, SpongeBob, Jimmy, Timmy and B.O.B. hide in their HQ in a split second (not-seen). When Sheen informs a plan, SpongeBob, Jimmy, Timmy and B.O.B. were not there then Jenny comes in. Jenny was asking Sheen a favor, but Sheen panics slightly, avoiding getting touched. He jumps on Chester, sacrifices Patrick to Jenny by getting touches and went off to find help. Jenny releases Patrick and leaves. Patrick itches, SpongeBob, Jimmy, Timmy and B.O.B. hack him in their HQ with a rope, raised the alarm and placed Patrick in a box to avoid getting cooties. When B.O.B., Jimmy and Timmy panic that they were infected when Jenny visited them earlier and run around, SpongeBob slaps them to snap out and slaps Jimmy's oxygen mask off. Jimmy takes Timmy's and Timmy uses a goldfish bowl to cover his head. Since none of them are itching, SpongeBob informs that none of them have cooties until B.O.B. itches and is put in the box (dropped and sat on Patrick).
Chester and Sheen ask the gorillas for help until Jenny comes in. Chester and Sheen run in terror while Jenny itches at the tree, making the gorillas stand back in terror. While Fanboy and Chum Chum were playing checkers, Sheen jumps in, ruins the game and tells them that Jenny is coming. Jenny comes in so Sheen, again, runs in terror. Jenny asks the chimps to scratch her back, but Fanboy and Chum Chum refuse to get touched by cooties and Jenny then realizes about it. At the Toy Shop, Sheen piles up a pile of toys and itches, meaning he has the cooties.
Meanwhile, in the HQ, the clocks ticks with Jimmy and Timmy performing reacting movements from each tick. Jimmy itches his hair and is put in the box (just like B.O.B., he sat on Patrick when he was dropped in). While SpongeBob talks to them, Timmy secretly vomits out a back scratcher, a rake and a cactus to scratch his back and throws it away when SpongeBob looks back at him. When B.O.B. and Jimmy put up a mirror and show that Timmy is scratching his tongue with the cactus, he was spotted and is put in the box (but instead of seen being dropped, the scene shows it was getting full as B.O.B. asks for a back scratch). As SpongeBob reports on SpongeBob's log, Jenny comes in and asks SpongeBob to scratch her back. Jenny chases SpongeBob (while B.O.B. appreciates his back scratch) then SpongeBob uses a bomb to mist the place and crawl away, but Jenny touches. SpongeBob informs he's infected and tries to get in the box. Jenny grumpily leaves the HQ (and scratches her back on the wall before 'fully' leaving).
At her house, the zookeeper spots Jenny itching and grabs her. Jimmy, Timmy and B.O.B. (with SpongeBob, who has got in) hear Jenny scream and jump out (with Patrick squashed then scratches his itch). SpongeBob, Jimmy, Timmy and B.O.B. were spotted itching and are taken along with Jenny. They were placed in an oatmeal bath. SpongeBob owes Jenny an apology one day. A zookeeper informs that the leaves Jenny had earlier were poison ivy, Jenny's so-called moisturizing plant. Jenny owes the others an apology as B.O.B. informs they should tell Sheen about the poison ivy, but SpongeBob would rather relax.
At the Toy Shop, Sheen, Chester and the rest of the Nicktoons itch badly while Sheen screams, "Curse... you... COOOOOOOOOOTIEEEEESSS!"
- SpongeBob SquarePants
- Jimmy Neutron
- Timmy Turner
- B.O.B. (Benzoate Ostylezene Bicarbonate)
- Jenny (XJ-9) Wakeman
- Sheen Estevez
- Chester McBadbat
- Patrick Star
- Burt the Elephant (no lines)
- Chum Chum
- Bloo (Voice by Keith Ferguson)
- The gorillas
- Other Nicktoons
- SpongeBob, Jimmy, Timmy and B.O.B.'s Headquarters
- Sheen's house
- Jenny's house
- The Gorilla pen
- Fanboy and Chum Chum's house
- The Toy Shop
- The Hospital